Yearbook of Intensive Care and Emergency Medicine 2009 by Vincent J.-L. (ed.)

By Vincent J.-L. (ed.)

The Yearbook compiles the latest advancements in experimental and scientific study and perform in a single finished reference booklet. The chapters are written through good famous specialists within the box of in depth care and emergency drugs. it truly is addressed to every body keen on inner drugs, anesthesia, surgical procedure, pediatrics, extensive care and emergency drugs.

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Yearbook of Intensive Care and Emergency Medicine 2009

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Reactive Oxygen Species The mitochondrial electron transport chain is one of the pathways that produces oxidants and free radicals in the body. Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, are toxic by-products of cellular metabolism. At complex I and III of the mitochondrial electron transport chain, electrons may leak to molecular oxygen, causing the production of superoxide. Approximately 1 – 2 % of the oxygen consumed by mitochondria is converted to ROS. As ROS function as cellular messengers, they can broadly influence gene expression, cell proliferation, energy metabolism and mitochondrial biogenesis.

Biochem J 404: 345 – 351 23. Elson JL, Turnbull DM, Howell N (2004) Comparative genomics and the evolution of human mitochondrial DNA: assessing the effects of selection. Am J Hum Genet 74: 229 – 238 24. Kivisild T, Shen P, Wall DP, et al (2006) The role of selection in the evolution of human mitochondrial genomes. Genetics 172: 373 – 387 25. Amo T, Yadava N, Oh R, Nicholls DG, Brand MD (2008) Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T.

Haplogroups and Mitochondrial Function Evidence has emerged, over recent years, to link different mtDNA haplogroups with alterations in the phenotypic expression of mitochondrial activity. Leber hereditary optic neuropathy (LHON) is a rare cause of inherited blindness primarily due to three pathogenic mtDNA mutations (11778G>A, 14484T>C and 3460G>A). The penetrance of the 11778G>A and 14484T>C mutations is markedly influenced by the background mtDNA haplogroup [32]. Sperm motility is strongly dependent upon ATP supplied by oxidative phosphorylation activity.

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