Bioactive Compounds from Terrestrial Extremophiles by Lesley-Ann Giddings, David J. Newman

By Lesley-Ann Giddings, David J. Newman

A dialogue of the chemicals produced via organisms residing below severe stipulations that can have strength as medicines or ends up in novel medicinal drugs for human use. This SpringerBrief bargains with bioactive fabrics from terrestrial extremophiles.

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Extra info for Bioactive Compounds from Terrestrial Extremophiles

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Versutus strain ALJ 15 Alkaliphile Table 4 (continued) Bioactivity N/A N/A Compound Natronochrome 110 Chloronatronochrome 111 Takaichi et al. (2004) References Takaichi et al. (2004) 40 Bioactive Compounds from Terrestrial Extremophiles 5 Alkaliphiles 41 genomic sequencing (Foti et al. 2008; Siddaramappa et al. 2012; Takami et al. 2000; Keshri et al. 2013) of alkaliphiles from different environments have revealed diverse and novel taxon and genes, many of which are unexplored sources of new chemical entities.

Pennicitrinone C O 141. Actinopolysporin B HO HO O O OH O O O 142. Actinopolysporin C O O O O O O N H O HO NH O C7' O O O HO O N O OH O N N OH 143. Neaumycin N HO OH O O 145. Terremide B 144. Terremide A O HO O OH 146.  9 Structures 135–146 Compound 138 is a pentacyclic molecule possessing a pyrone ring as well as a lactone ring with a methoxy group attached, while pennicitrinone C 138 possesses an open-ring lactone without a methoxy group. 3 μM. Several other reports on either the bioactivity and/or isolation of novel, structurally complex molecules from halophiles have been published (Meklat et al.

7 2 2 2 Penicillium rubrum P. rubrum P. rubrum Chlorella mutabilis-associated Penicillium sp. P. rubrum; Penicillium sp. IMU-0035 P. rubrum P. rubrum P. rubrum P. rubrum P. solitum P. purpurogenum P. purpurogenum P. purpurogenum Acidophile Table 3 Bioactive compounds isolated from terrestrial acidophiles Berkeleyamides A–D (76–79) Berkazaphilones A–C (80–81; 84) Berkedienoic acid 82 Berkedienolactone 83 Berkedrimanes A and B (85–86) Purpurquinones A–C (87–89) Purpuresters A and B (90–91) 2,6,7-Trihydroxy-3methylnapthalene-1,4-dione 92 Berkeleyacetals A–C (73–75) Berkeleyones A–C (69–71) Berkelic acid 72 Berkeleytrione 68 Compound Berkeleydione 67 Anti-viral against influenza A (88–89) Anti-viral against influenza A (90) N/A N/A N/A Casp-1 and casp-3 inhibitor Stierle et al.

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