By Lesley-Ann Giddings, David J. Newman
This SpringerBrief sheds new mild on bioactive fabrics from extremophiles with the focal point at the biosynthesis approaches and comparable genomics. It bargains with all elements of the chemicals produced by way of organisms dwelling lower than severe stipulations that could have capability as medications or result in novel medications for human use.
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Extra info for Bioactive Compounds from Extremophiles: Genomic Studies, Biosynthetic Gene Clusters, and New Dereplication Methods
2013) He et al. (2001), Woo et al. (2012) Rath et al. (2011) Olivera et al. (1987) Kishi et al. (1995) Kaselein et al. (2014) References Suckling (1991), Bergmann and Feeney (1950, 1951), Bergmann and Burke (1955) Cimino et al. (1984) 46 Bioactive Compounds from Extremophiles 5 Summary and Concluding Remarks 47 reduce amplification biases and chimeric DNA rearrangements as well as improve de novo assembly. Importantly, because the amount of data generated by NGS technologies will continue to increase exponentially, new bioinformatics tools are being developed to analyze the taxonomic content of large metagenomic datasets (Metagenome analyzer, MEGAN) (Huson et al.
2012) Protoporphyrin IX 52 N/A He et al. (2012) Apratoxin A 53 Cytotoxic Luesch et al. (2001) Onnamide A 54 Antiviral; cytotoxic Sakemi et al. (1988), Burres and Clement (1989) N/A information not available clusters involved in secondary metabolism holds significant potential for finding new drug candidates. For more details on using metagenomics to exploit uncultivated eubacteria, see the latest 2013 review by Wilson and Piel (2013) and 2014 reviews from the Brady group (Charlop-Powers et al.
Notably, genomic data are being used as blueprints for metabolic engineering, eliminating different competitive pathways and modifying transcription and translation machinery in the microbial host to increase the production of secondary metabolites. Scientists are now recognizing that the integration of tools, such as bioassays, metagenomics, single-cell analysis, metatranscriptomics, metaproteomics, metabolic engineering, metabolomics, and heterologous gene expression, has become necessary to uncover the biosynthetic potential of uncultivatable microorganisms, streamlining the drug discovery process.