By Lena Palaniyappan
Following the hot alterations to the syllabus and MRCPsych examination by way of the Royal collage of Psychiatrists, this booklet includes 450 a number of selection inquiries to support psychiatry trainees to arrange for Paper three of the examination. assisting those MCQs are designated explanatory solutions and revision notes, referenced to the main textbooks utilized by trainees. The book's content material is heavily matched to the MRCPsych syllabus and comprises perform papers for real examination practise.
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Phosphodiesterase-5 (PDE-5) is an enzyme found in the trabecular smooth muscle of the penis. It catalyses the degradation of cGMP, which results in an elevated cytosolic calcium concentration and muscular contraction leading to erection. PDE-5 inhibitors such as sildenaﬁl, vardenaﬁl, and tadalaﬁl block this biochemical pathway to promote erection. Sildenaﬁl and vardenaﬁl must be taken 1 hour before sexual activity to enable their action. Alprostadil is prostaglandin E1, which causes smooth muscle relaxation and subsequent vasodilation by acting on adenylate cyclase to increase the intracellular cyclic adenosine monophosphate (cAMP) concentration.
Conventional antidepressants have also been reported to have a therapeutic effect in SAD. Stein G and Wilkinson G, eds. Seminars in General Adult Psychiatry, 2nd edn. Gaskell, 2007, p. 13. Rodin I and Thompson C. Seasonal affective disorder. Advances in Psychiatric Treatment, 1997; 3: 352–359. 22 GENERAL ADULT PSYCHIATRY | ANSWERS 4. C. Dysthymia has a 1-year prevalence of 1–3%. The lifetime prevalence according to the National Comorbidity Survey 1994 is 6%. Dysthymia has a high comorbidity with other psychiatric disorders, particularly major depression.
Seminars in General Adult Psychiatry, 2nd edn. Gaskell, 2007, p. 91. GENERAL ADULT PSYCHIATRY | ANSWERS 38. C. Data from the Ofﬁce of National Statistics from 1993–2002 have demonstrated a signiﬁcantly higher rate of fatal overdose (fatal toxicity index) with the antidepressant venlafaxine than with SSRIs. Venlafaxine has a similar lethality to TCAs in cases of overdose; most deaths are ascribed to cardiac effects of the drug. Overall, approximately 10% of venlafaxine overdoses that are reported have proven fatal.