Animal Models of Diabetes: Frontiers in Research, 2nd by Eleazar Shafrir

By Eleazar Shafrir

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Additional info for Animal Models of Diabetes: Frontiers in Research, 2nd edition

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1999) Lack of association between duration of breastfeeding or introduction of cow’s milk and development of islet autoimmunity. Diabetes 48:2145–2149. Courtois P, Nsimba G, Jijakli H, et al. (2005) Gut permeability and intestinal mucins, invertase, and peroxidase in control and diabetes-prone BB rats fed either a protective or a diabetogenic diet. Dig Dis Sci 50:266–275. fm Page 28 Thursday, March 1, 2007 4:03 PM 28 Animal Models of Diabetes Cremer MA, Ye XJ, Myers LK, et al. (2004) T cell immunity to type II collagen in the biobreeding rat: The identification and characterization of RT1u-restricted T cell epitopes on α1(II).

Diabetologia 47:1331–1333. Burstein D, Handler ES, Schindler J, et al. (1987) Effect of interleukin-2 on diabetes in the BB/Wor rat. Diabetes Res 5:163–167. Burstein D, Mordes JP, Greiner DL, et al. (1989) Prevention of diabetes in the BB/Wor rat by a single transfusion of spleen cells: Parameters that affect the degree of protection. Diabetes 38:24–30. Buschard K, Blomqvist M, Osterbye T, et al. (2005) Involvement of sulfatide in beta cells and type 1 and type 2 diabetes. Diabetologia 48:1957–1962.

1996). NOD mice model interactions with the environment largely in support of the hygiene hypothesis because the great majority of perturbants, including viral infection, reduce the frequency of diabetes and often prevent it entirely (Atkinson and Leiter 1999). A toxin-inducible model is the mouse treated with multiple small doses of streptozotocin (STZ) (Mordes et al. 2000). Because this induction method can lead to diabetes in NOD-scid mice that have no functional lymphocytes, its relevance as a model of T1D is doubtful (Gerling et al.

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