By Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
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Additional resources for An Introduction to Genetic Analysis
Comparing the child to the parents, we see that the child inherited copy M1 from its mother and copy F2 from its father. Look closer at the child’s two copies of the segment, and you’ll notice something else. There is a unique variant (red letter) that occurs in the child but neither of its parents. This is a de novo point mutation. It this case, it is a mutation from a guanine (G) to a thymine (T). We can see that the mutation arose in the father since it is on the F2 copy of the segment. Where and exactly when did the new mutation depicted in Figure 1-17 arise?
QTL have alleles that usually engender only partial changes such as the difference between a pale purple and a medium purple. Using QTL mapping, Mackill learned that the secret to FR13A exceptionalism was mostly due to a single genetic locus or QTL on one of the rice chromosomes. ” With the chromosomal location of SUB1 revealed, it was time to delve even deeper and identify the molecular nature of SUB1. What type of protein did it encode? How did the allele of SUB1 found in FR13A allow the plant to cope with submergence?
The older the father, the higher the frequency of new point mutations (Figure 1-18). In fact, for F I G U R E 1-17 A short segment of DNA from one of the chromosomes is shown. Each individual has two copies of the segment. In the mother, these are labeled M1 and M2; in the father, F1 and F2. The child inherited copy M1 from its mother and F2 from its father. The version of F2 in the child carries a new point mutation (red). Single nucleotide polymorphisms (SNPs) that distinguish the different copies are shown in green (mother) and purple (father).